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Ultrafine anaphase bridges

Web30 Jan 2024 · Resolution of ultrafine anaphase bridges (UFBs) must be completed before cytokinesis to ensure sister-chromatid disjunction. RIF1 is involved in UFB resolution by a … Web12 Mar 2015 · Here, the authors report that topoisomerase IIβ binding protein 1 recruits topoisomerase IIα to centromere-associated ultra-fine anaphase bridges to enable their …

Detection of Ultrafine Anaphase Bridges SpringerLink

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BLM is required for faithful chromosome segregation and its ...

Web25 Sep 2024 · Ultrafine anaphase bridges (UFBs) are a potential source of genome instability that is a hallmark of cancer. UFBs can arise from DNA catenanes at … WebEventually, in mitosis, they can evolve into ultrafine anaphase bridges (UFBs) connecting sister chromatids, which can finally lead to chromosomal instability. In the following sections, we focus on CFSs as an example of the extraordinary processes that cells carry out in mitosis to resolve problems that originated during the previous S-phase, in order to … Web1 Jun 2024 · Although chromatin bridges and lagging chromatin are always pathological (generating aneuploidy or complex genomic rearrangements), the main subject of this article, the ultrafine anaphase bridges, might, in addition to potentially driving genomic instability, play critical roles for the maintenance of chromosome structure in rapidly ... edge insecurecontentallowedforurls

Ultrafine anaphase bridges, broken DNA and illegitimate …

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Ultrafine anaphase bridges

Topoisomerase IIα prevents ultrafine anaphase bridges …

Web(A) HeLa cells were transfected with siControl or siTDP-43 and ultrafine anaphase bridges (UFBs) were visualized using both anti-PICH and anti-BLM antibodies. Representative … Web12 Mar 2015 · Thus far TOPBP1 localisation to ultra-fine anaphase bridges (UFBs) has been reported only in yeast Saccharomyces cerevisiae and the transformed avian B-lymphoblastoid cell line DT40 16. Therefore, we decided to test if this was also the case in human transformed and importantly, primary cells.

Ultrafine anaphase bridges

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Webuntil anaphase and give rise to a high frequency of UFBs that are decorated with PICH, BLM and RPA (Figure 2). They were termed homologous recombination ultrafine bridges (HR-UFBs) to dis-tinguish them from centromeric UFBs, replication stress-associated UFBs, and telomeric UFBs (Figure 1). In parallel with these studies, work from Web2 Mar 2024 · The journal paper, entitled ‘RIF1 Suppresses the Formation of Single-Stranded Ultrafine Anaphase Bridges via Protein Phosphatase 1’, can be found at the following link: …

WebAbout. I am a postdoctoral fellow in the Cappell lab at the NIH, Bethesda, US. We are working on the cell cycle with special interest in regulators governing the induction of senescence. … WebNew insights into the formation and resolution of ultrafine anaphase bridges. Semin Cell Dev Biol (2011), 22(8): 906-12. Chan KL, Hickson ID. On the origins of ultra-fine anaphase …

WebPreviously, anaphase bridges were presumed to be a rare occurrence, however, recent evidence has shown that in most mitosis ultrafine anaphase bridges (UFBs) are … WebT1 - Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier. AU - Sofueva, Sevil. AU - Osman, Fekret. AU - Lorenz, Alexander. AU …

Web21 Mar 2024 · If not timely processed, these DNA joint molecules can give rise to the so-called ultrafine anaphase bridges (UFBs), which are fine DNA threads that cannot be …

Web1 Jan 2024 · Ultrafine anaphase bridges (UFBs) are thin DNA threads linking the separating sister chromatids in the anaphase of mitosis. UFBs are thought to form when topological … edge insecure downloadWeb25 Sep 2024 · Ultrafine anaphase bridges (UFBs) are a potential source of genome instability that is a hallmark of cancer. UFBs can arise from DNA catenanes at … edge insecurelyWebUltrafine anaphase bridges (UFBs) result from a defect in sister chromatid segregation during anaphase. They arise from particular DNA structures, mostly generated at specific … conghoacampus1