WebOct 2, 2024 · Ferroptosis belongs to a novel form of regulated cell death. It is characterized by iron dependence, destruction of intracellular redox balance and non-apoptosis. And cellular structure and molecules level changes also occur abnormally during ferroptosis. It has been proved that ferroptosis exist widespreadly in many diseases, such as heart … WebThis Opinion article overviews the main metabolic processes in ferroptosis, summarizes the emerging roles of ferroptosis not only in immune cells in the TME but also in the crosstalk between tumor cells and immune cells, and presents a perspective on the targeting of ferroptosis in cancer immunotherapy. Keywords:
Novel insights on targeting ferroptosis in cancer therapy
WebApr 7, 2024 · Ferroptosis induced active-immune TME and sensitizes the tumors to αPD-L1 treatment. A) A schema to illustrate the experiment. 1 × 10 6 of MTCQ1-2 cells were inoculated into the subcutaneous region of the B6 mice. Intratumoral injection of FIN56 (100 mg kg −1) was administered on the 15th day and 17th day. Mice were sacrificed on the … WebMar 4, 2024 · Necrotic cell death during Mycobacterium tuberculosis (Mtb) infection is considered host detrimental since it facilitates mycobacterial spread. Ferroptosis is a … promedic resting splint
Ferroptosis-related gene signature for head and neck carcino IJGM
WebMay 1, 2024 · Together, these results show that CD36-mediated ferroptosis of tumor-infiltrating CD8 + T cells limits antitumor immunity and suggest that blocking this pathway may enhance antitumor immune function alone or … WebNov 2, 2024 · Ferroptosis is a ROS-dependent form of cell death associated with the accumulation of excessive iron and lipid peroxidation, as well as changes in specific … WebFerroptosis, necroptosis, and pyroptosis represent the newly discovered immunogenic cell death (ICD) forms. Promoting ICD may alter the tumor microenvironment (TME) and the influx of TILs, and combination of their inducers and ICIs plays a synergistical role in enhancing antitumor effects. Nevertheless, the combination of the above two ... promedic wipes