Siglecs are Type I transmembrane proteins where the NH3 -terminus is in the extracellular space and the COO -terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of … See more Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. There are 14 … See more The first described candidate Siglec was Sialoadhesin (Siglec-1/CD169) a lectin-like adhesion protein on macrophages. Parallel studies by Ajit Varki and colleagues on the previously cloned CD22 (a B cell surface protein involved in adhesion and activation) showed direct … See more Many pathologies have been linked to the spontaneous interactions between sialic acid and the immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on immune cells such as cancer, HIV-1 and Group B Strep Infection. The See more The primary function of Siglecs is to bind glycans containing sialic acids. These receptor-glycan interactions can be used in cell adhesion, cell … See more This table briefly summarises the cellular distribution of each human/primate Siglec; the linkage specificity each has for sialic acid binding; the number of C2-Ig domains it contains; and … See more • Functional Glycomics Gateway, a collaboration between the Consortium for Functional Glycomics and Nature Publishing Group See more WebMay 1, 2006 · We describe the cloning and characterization of Siglec-H, a novel murine CD33-related siglec-like molecule with 2 immunoglobulin domains. Unlike other CD33 …

Sialic acid–binding immunoglobulin-like lectins (Siglecs ... - Springer

WebSep 5, 2024 · For the purpose of further investigating the biological function of Siglec-15 on macrophage and tumor progression of PDAC, we then established a series of tumor … WebMultiparameter flow cytometric analysis of Siglec-9 (CD329) expression on Human peripheral blood leucocyte populations. Human whole blood was stained with either BD Horizon™ BV421 Mouse IgG1, κ Isotype Control (Cat. No. 562438; Left Plot) or BD Horizon™ BV421 Mouse Anti-Human Siglec-9 (CD329) antibody (Cat. No. 569521/569522; Right Plot). dynamics solomon

Discovery of an agonistic Siglec-6 antibody that inhibits and …

WebI-type lectins are defined as glycan-binding proteins (excluding antibodies and T-cell receptors) in which the binding domain is homologous to the large and varied immunoglobulin superfamily (IgSF) of proteins. Among I … WebSialic acid–binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of white blood cells of the immune system and play critical roles in immune cell signaling. … WebThe biological role of Siglec-1 will be explored later in this review in the context of innate immunity and also when discussing T cell activation; Siglec-4, which is expressed at high … cryz family tuscola texas