Tīmeklis2024. gada 22. jūl. · The first patients have been dosed in the phase 3 SPOTLIGHT trial, which is examining the investigational PSMA-targeted radiohybrid PET imaging agent rhPSMA-7.3 (18 F) in men with suspected prostate cancer recurrence. 1The single-arm SPOTLIGHT study (NCT04186845) is specifically assessing the safety and … TīmeklisBackground: 18 F-labeled prostate-specific membrane antigen (PSMA) positron emission tomography (PET) ligands offer a longer half-life and improved spatial …
Uptake of 18F-rhPSMA-7.3 in Positron Emission Tomography …
Tīmeklis2024. gada 13. febr. · 18 F-rhPSMA-7.3, an investigational radiohybrid PET imaging agent targeting prostate-specific membrane antigen, accurately detected distant metastatic lesions in 10% to 15% of newly diagnosed men with unfavorable intermediate to very high-risk prostate cancer. Tīmeklis18 F-rhPSMA-7.3 has a clinically meaningful correct detection rate that meets the prespecified threshold; While the region level positive predictive value does not meet the prespecified threshold, the data in patients with a composite Standard of Truth are limited by the high proportion of prostate/bed scans (92%) that relied on conventional ... fishermans view in sandwich
LIGHTHOUSE: Novel PSMA-Targeted PET Radiopharmaceutical …
Tīmeklis2024. gada 3. dec. · [18F]rhPSMA-7.3 can be used for imaging PSMAexpressing tumours, mainly primary and metastatic prostate cancer, but also non-prostate cancers due to PSMA expression in the neovasculature. As a radiohybrid (therefore the "rh" in the name; not to be confused with recombinant human PSMA) Tīmeklis2024. gada 12. apr. · 18 F-rhPSMA-7.3 is a prostate specific membrane antigen (PSMA)-targeted radiopharmaceutical in development for the imaging of patients with prostate cancer. 18 F-labelled PSMA PET radiopharmaceuticals are increasingly used in preference to their 68 Ga-labelled counterparts due to their favourable features, … Tīmeklis2024. gada 7. dec. · Since [18F, natGa]rhPSMA-7 is composed of four stereoisomers ([18F, natGa]rhPSMA-7.1, -7.2, -7.3 and -7.4), we initiated a preclinical selection process to identify the isomer with the most favorable pharmacokinetics for further clinical investigation. A synthetic protocol for enantiopure [19F, natGa]rhPSMA-7 … fisherman svg