Phkg2 ferroptosis

Author: gusr

August undefined, 2024

WebbFerroptosis, a newly discovered iron-dependent form of cell death, contributes to various pathologies; however, the prognostic value of ferroptosis-related genes (FRGs) in cervical cancer (CC) remains unclear. Herein, we identified 15 differentially expressed FRGs based on data from The Cancer Genome Atlas database. Webb1 jan. 2024 · Ferroptosis is an iron-dependent non-apoptotic cell death that can elicited by pharmacological inhibiting the cystine/glutamate antiporter, system Xc − (type I) or directly binding and loss of activity of GPx4 (Type II) in cancer cells with high level RAS-RAF-MEK pathway activity or p53 expression, but not in normal cells.

WP_FERROPTOSIS - GSEA MSigDB

Webb21 mars 2024 · PHKG2 (Phosphorylase Kinase Catalytic Subunit Gamma 2) is a Protein Coding gene. Diseases associated with PHKG2 include Glycogen Storage Disease Ixc … WebbWe identified PHKG2 as a crucial regulator of ferroptosis in H. pylori-positive GC. Its expression is correlated with patient survival and ICI therapeutic response. … dutch reformed church poughkeepsie

Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis

Webb1 aug. 2024 · What is both intriguing and fascinating is the role of phosphorylase kinase G2 (PHKG2), an enzyme that induces the release of glucose-1-phosphate from glycogen, in … Webb3 feb. 2024 · Ferroptosis is a newly identified iron-dependent cell death that is different from other cell death forms, including apoptosis and necrosis. The program involves three primary metabolisms... Webb28 juni 2024 · Ferroptosis is a new type of iron-dependent programmed cell death. ... proteomic sequencing analysis and OP-B administration showed the up-regulation of AURKA and down-regulation of PHKG2 and SLC7A5 in the 12-gene signature, indicating that OP-B induced NSCLC ferroptosis. Determination of malondialdehyde (MDA), … crysis intro

Unsolved mysteries: How does lipid peroxidation cause …

Prognostic and immune implications of a novel ferroptosis

Webb20 mars 2024 · In conclusion, PHKG2 facilitates RSL3-induced ferroptosis in H. pylori-positive GC cells by promoting ALOX5 expression. These findings may contribute to a better understanding of the unique pathogenesis of H. pylori-induced GC and allow for maximum efficacy of genetic, cellular, and immune therapies for controlling ferroptosis … crysis imagesWebbPHKG2 is a key regulator of tumor development and immunotherapy response in H. pylori- related GC. • PHKG2 facilitates RSL3-induced ferroptosis in H. pylori positive GC cells by promoting ALOX5 expression. • These findings may contribute to a better understanding of the unique pathogenesis of H. pylori- induced GC. Abstract crysis launch properties

"Webb22 dec. 2024 · Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis, necrosis, pyroptosis, and autophagy. Ferroptosis is characterized by iron-dependent oxidative destruction of cellular membranes following the … " - Phkg2 ferroptosis

Phkg2 ferroptosis

Induction of Ferroptosis by Ophiopogonin-B Through Regulating

Webbför 2 dagar sedan · In this study, we assume that deep learning model learns the nonlinear interaction between molecular environment (expression profile of ferroptosis regulators) and ferroptosis regulation score (potential regulation level of ferroptosis), so as to make accurate prediction. Webbferroptosis inducers inhibit GPX4 by covalently targeting the active site selenocysteine, leading to accumulation of PUFA hydroperox-ides. In summary, we found that PUFA oxidation by lipoxygenases via a PHKG2-dependent iron pool is necessary for ferroptosis and that the covalent inhibition of the catalytic selenocysteine in Gpx4

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Webb22 dec. 2024 · Phosphorylase kinase G2 (PHKG2) can regulate iron availability of lipoxygenase, including arachidonate LOX12 (ALOX12), ALOX12B, ALOX15, and … WebbNational Center for Biotechnology Information

WebbAlthough some publications investigated the correlations between ferroptosis and LUAD, [10] [11][12][13] this study aimed to explore multi-omics data on LUAD including mRNA expression, protein ... WebbFerroptosis is a novel type of cell death in hepatic IRI that involves small molecules that inhibit glutathione biosynthesis or glutathione peroxidase 4 (GPX4), which is a glutathione‑dependent antioxidant enzyme, causing mitochondrial damage.

Webb9 aug. 2024 · In this study, we constructed a 15-gene prognostic signature predicting overall survival based on ferroptosis-related genes (ferroptosis driver genes VDAC2, … Webb10 aug. 2024 · The small molecule RSL3 has been identified as an inducer of ferroptosis and its MoA, that involves binding and inhibition of GPX4 , was recently reported (Yang et al. 2014) as determined by affinity-based proteomics. GPX4 could also be inhibited upstream as a result of the inhibition of selenoprotein (SELT), for instance by directly …

Webb30 apr. 2024 · Ferroptosis is an iron-dependent form of regulated cell death, which is driven by the lethal accumulation of lipid peroxidation ( 8 ). It is a novel death phenotype …

Webb24 juni 2024 · Ferroptosis, a form of programmed cell death induced by excess iron-dependent lipid peroxidation product accumulation, plays a critical role in cancer. … crysis ipadWebb28 juni 2024 · Ferroptosis is a new type of iron-dependent programmed cell death. In recent years, its role in the diagnosis and treatment of multiple tumors, including non … dutch reformed church tarrytownWebb31 aug. 2024 · A ferroptosis-related gene signature for overall survival prediction and immune infiltration in lung squamous cell carcinoma A ferroptosis-related gene … crysis initial release dateWebb5 nov. 2024 · PHKG2 is a regulator of polyunsaturated fatty acid peroxidation during ferroptosis, and silencing PHKG2 attenuates U-2-OS cell sensitivity to Erastin. 18 HSD17B11 is an enzyme involved in reduction or oxidation of sex hormones and is reported to be enriched in RSL3-resistant cells. 19 STEAP3, a metalloreductase capable of … crysis keyboard controls fullscreenWebb24 maj 2024 · Ferroptosis is a cell death process driven by damage to cell membranes and linked to numerous human diseases. Ferroptosis is caused by loss of activity of the key … dutch reformed church rhinebeck nyWebb5 apr. 2024 · Ferroptosis-related gene is an iron-dependent regulatory tumor cell death, driven by the lethal accumulation of lipid peroxidation . Previous literature reported that … dutch reformed church vredenburgWebb30 juli 2024 · Ferroptosis is characterized by iron accumulation, excessive production of ROS, and lipid peroxidation. This illustration shows the process of ferroptosis, summarizing the key molecules and targets regulating iron and lipid peroxidation. crysis investigate the alien structure