WebDec 16, 2014 · A method for the iridium-catalyzed silylation of aryl C–H bonds is described. The reaction of HSiMe(OSiMe3)2 with arenes and heteroarenes catalyzed by the … WebLater, Hartwig and co-workers further applied this strategy to the iridium-catalyzed, β-C(sp 3)–H silylation of aliphatic amines to prepare 1,2-amino alcohols by utilizing a methylene linkage between the silyl group and nitrogen atom. 33 Enantiopure 1,2-amino alcohols could be furnished at or even below room temperature by employing electron ...
Mechanism of the Rhodium-Catalyzed Silylation of Arene …
WebNov 3, 2024 · In this Minireview, we present the rapid development of enantioselective silylation and borylation of C−H bonds, with an emphasis on the design and … WebTransition-metal-catalyzed enantioselective C–H silylation is one of the most effective ways to access silicon-containing chiral molecules, which have great utility in areas ranging from synthetic chemistry and medicinal chemistry to materials science. flight dxb to ruh
Transition-metal-catalyzed enantioselective C−H silylation
WebHartwig, J.F., Romero, E.A. Iridium-catalyzed silylation of unactivated C-H bonds. Tetrahedron 2024 , 75 , 4059-4070. 406. Karmel, C., Chen, Z., Hartwig, J.F. Iridium-Catalyzed Silylation of C–H Bonds in Unactivated Arenes: A Sterically Encumbered Phenanthroline Ligand Accelerates Catalysis. J. Am. Chem. Soc. 2024 , 141 , 7063 … WebFeb 14, 2024 · In particular, Hartwig and coworkers 28 have successfully developed a rhodium/bisphosphine catalyzed reaction between MeSiH (OTMS) 2 and various arenes, which demonstrated a broad C–H bond scope... WebJun 19, 2012 · Based on this hypothesis, we studied catalysts containing substituted phenanthroline ligands for a series of additional transformations, including the silylation … chemist receipt