Dynamics of an oncolytic virus model
WebAug 15, 2024 · Oncolytic viruses (OVs) offer a novel strategy for the treatment of HCC. The OVs have an inherent ability to cause direct tumor cell lysis while sparing normal … Webthe viral lytic cycle based on a basic oncolytic virus dynamics model. We conduct a detailed analysis for the dynamics of the model and carry out numerical simulations ... In this study, building on a basic mathematical model for oncolytic viral dynamics (Tian 2011; Wang et al. 2013), we combine the viral lytic cycle, tumor cell diffusion, ...
Dynamics of an oncolytic virus model
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WebOncolytic viruses are of growing interest to cancer researchers and clinicians, due to their selectivity for tumor cells over healthy cells and their immunostimulatory properties. The …
Webwork. A predictive model of a complex in vivo situation (e.g. including immune responses) will obviously be more difficult to attain, but can arise from a thorough understanding of … WebMar 22, 2016 · Basic model of virus dynamics, and its application to oncolytic virus dynamics. A basic framework to study virus dynamcis in the context of a variety of human pathogens 11 takes into account three populations: uninfected cells, x, infected cells, y, and free virus, v. The model is given by ordinary differential equations, that describe the ...
WebDec 6, 2024 · Author summary Oncolytic virotherapy is a promising form of cancer treatment that uses viruses to target, infect and kill cancer cells. Unfortunately, this form of therapy is often not effective, due to the occurrence of virus-resistant tumor cells. As it is challenging to assess the emergence and spread of resistance experimentally or in … WebMay 15, 2024 · There are various papers dealing with mathematical models applied to the dynamics of the oncolytic viruses on tumor cells. For example, [10] studied an ordinary differential equation (ODE) model ...
WebMar 15, 2003 · Additional oncolytic virus species in development include vesicular stomatitis virus, polio virus, measles virus, Newcastle disease virus, ... The essential dynamics of the model are as follows. We assume that the uninfected tumor cells proliferate at rate λ. The virus infects tumor cells by binding to receptors on cell surfaces …
WebApr 6, 2024 · Oncolytic virus therapy (OVT) is a novel immunotherapy that uses natural or genetically modified viruses to specifically infect and lyse cancer cells but does not harm normal cells. 12 Some ... cynthia sharp attorneyWebSep 21, 2024 · To this end, we developed a delay differential equation model that describes the dynamics of the oncolytic virus that is not 100% tumor-specific on normal and tumor cell populations. A major focus of our model analysis was to explore and delineate the effects of oncolytic potency and specificity of viruses that not 100% tumor-specific in ... cynthia shaw canton ilWebSep 9, 2024 · Cancer has always been an enormous threat to human health and survival. Surgery, radiotherapy, and chemotherapy could improve the survival of cancer patients, but most patients with advanced cancer usually have a poor survival or could not afford the high cost of chemotherapy. The emergence of oncolytic viruses provided a new strategy for … cynthia sharp facebookWebJun 14, 2012 · One can model the spatial dynamics by the following equations, where parameters r, , a, and k are the rates of division, infection and death, and the local carrying capacity. They are the same as in the metapopulation model. ... Komarova NL, Wodarz D (2010) ODE models for oncolytic virus dynamics. J Theor Biol 263: 530–543. cynthia sharp esqWebEquid alphaherpesvirus 1 (EHV-1) causes respiratory diseases, abortion, and neurological disorders in horses. Recently, the oncolytic potential of this virus and its possible use in anticancer therapy has been reported, but its influence on cytoskeleton was not evaluated yet. In the following study, we have examined disruptions in actin cytoskeleton of … cynthia sharpe attorneyWebMar 5, 2024 · Author summary Tumor therapy with replicating oncolytic viruses is based on the premise that if the tumor specific virus infects and is amplified by the tumor population and spreads sufficiently within the tumor, it will lead to eradication of the cancer. The outcome of this approach is an exercise in population dynamics, and, as in ecology, … biltong beef shelf lifeWebDec 18, 2024 · Oncolytic viruses (OVs) are an emerging class of therapeutics which combine multiple mechanisms of action, including direct cancer cell-killing, immunotherapy and gene therapy. A growing number of clinical trials have indicated that OVs have an excellent safety profile and provide some degree of efficacy, but to date only a single OV … biltong chilli sticks