Cytoglobin function
WebAbstact. Cytoglobin (CYGB) is a recently discovered vertebrate globin distantly related to myoglobin with unknown function. CYGB is assigned to chromosomal region … WebMar 31, 2024 · cytoglobin antioxidant function relied on the same reductive pathway and did not recruit and was not reliant on alternate pathways. The ability of cytoglobin to …
Cytoglobin function
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WebMay 16, 2024 · Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress ( Trent and Hargrove, 2002 ). Cloning and Expression WebMay 20, 2013 · Background. Evidence suggests that cytoglobin (Cygb) may function as a tumor suppressor gene. Methods. We immunohistochemically evaluated the expression of Cygb, phosphatidylinositol-3 kinase (PI-3K), phosphorylated (p)-Akt, Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and vascular endothelial growth factor (VEGF) in 88 …
WebCytoglobin (Cgb), a newly discovered member of the vertebrate globin family, binds O 2 reversibly via its heme, as is the case for other mammalian globins (hemoglobin (Hb), myoglobin (Mb) and neuroglobin (Ngb)). While Cgb is expressed in various tissues, its physiological role is not clearly understood. Here, the X-ray crystal structure of wild type … WebDec 28, 2024 · Abstract Cytoglobin (Cygb) was discovered as a novel type of globin that is expressed in mammals; however, its functions remain uncertain. While Cygb protects against oxidant stress, the basis for this is unclear, and the effect of Cygb on superoxide metabolism is unknown.
WebCytoglobin consumes NO through its dioxygenase activity, whereby oxycytoglobin (reduced cytoglobin with O2 bound) reacts with NO, resulting in the oxidation of the heme group and formation of nitrate as a byproduct. From: Nitric Oxide (Third Edition), 2024 Related terms: Fibroblast Myoglobin Nitric Oxide Nitrite Reductase Myofibroblast Neuroglobin WebCytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions Cytoglobin (Cygb) is a novel member of the vertebrate globin superfamily. Although it is expressed in splanchnic fibroblasts of various organs, details of its function remain unknown.
WebWe identified a novel function of cytoglobin (Cygb) as an efficient superoxide dismutase (SOD) with a high–bimolecular dismutation rate on the order of 10 8 M −1 ⋅ s −1. It is the …
WebApr 18, 2024 · Although conserved in most vertebrates, the function of cytoglobin is yet unknown. The changes in heme coordination lead to properties not consistent with an oxygen transport role, and a number of functions such as scavenging of reactive oxygen species, nitrite reduction, and nitric oxide dioxygenation have been proposed. little angels nursery redditchWebOct 13, 2024 · Cytoglobin has potent superoxide dismutase function. TGF-beta1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma. little angels nursery southwarkWebSep 15, 2008 · Cytoglobin (CYGB) is a recently discovered vertebrate globin distantly related to myoglobin with unknown function. CYGB is assigned to chromosomal region … little angels nursery tilbury essex vacanciesWebGlobins are ubiquitous heme-binding a-helical proteins whose function is principally thought to regulate oxygen homoeostasis [1, 2]. ... (Mb), cytoglobin (Cygb), and neuroglobin (Ngb). Hb is located in erythrocytes, which transport O 2 from the lungs to tissues through the circulatory system and CO 2 in the opposite direction. little angels nursery ofstedWebUsing independently derived antibodies, both report that Cygb is cytoplasmatically expressed in fibroblasts and fibroblast-related cell types in a broad variety of … little angels nursery thorntonWebJul 9, 2011 · Cytoglobin (Cygb) is a vertebrate globin with so far poorly defined function. It is expressed in the fibroblast cell-lineage but has also been found in neurons. little angels nursery stroudWebDec 7, 2016 · Cytoglobin (Cygb), identified as a new globin family member protein, is expressed in various tissues. Although its interaction with oxygen and nitric oxide indicates the potential role in antioxidant pathways, the exact role remains unclear. ... Cygb could serve an O 2 scavenging and supplying function, and could contribute to the ... little angels nursery stonehouse