WebWesternBlot分析显示贫铀接触后大鼠肾脏中TGF-β1、Smad、Timp-1、MMP-9均有不同程度的增加,而CTGF则无明显的改变。 TGF-β1目前被认为组织纤维化的主导因子,可在各个脏器组织中表达,其过度表达可通过各种途径引起肾小球硬化和肾间质纤维化。 WebApr 6, 2001 · We have identified a functional SMAD binding site in the CTGF promoter. TGFbeta-induction of CTGF is dependent on SMAD3 and SMAD4 but not SMAD2 and is …
Kinsenoside Protects Against Radiation-Induced Liver …
WebAug 6, 2024 · Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis. ... Thus, activation of CTGF increases phosph-Smad2/3, promoting transcription of Smad-responsive genes including CTGF itself. … WebAug 10, 2009 · Connective tissue growth factor (CTGF) plays a critical role in angiotensin II (Ang II)–mediated hypertensive nephropathy. The present study investigated the mechanisms and specific roles of individual Smads in Ang II–induced CTGF and collagen I expression in tubular epithelial cells with deletion of transforming growth factor (TGF)-β1, … dungeons and dragons gith
CTGF in kidney fibrosis and glomerulonephritis Inflammation and ...
WebOct 29, 2024 · Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, angiogenesis, and wound healing, as well as multiple pathologies, such as tumor development and tissue fibrosis. Although the underlying mechanisms of CTGF remain incompletely understood, … WebJun 29, 2024 · Connective tissue growth factor 2 (CTGF, CCN2), a member of the CCN family, is closely related to a variety of biological processes, including angiogenesis and … Web植物多酚缓解肝纤维化机制研究进展. 2024-11-24 毕秀丽 孙艳頔 刘怡菲 dungeons and dragons gold