Cisplatin renal clearance
WebMay 8, 2024 · Deliver hydration to patients receiving cisplatin therapy to maintain renal function. Include magnesium supplementation, which has nephroprotective effects in adults, in hydration regimens before, during, and after cisplatin. Add mannitol to hydration to prevent nephrotoxicity in adults. Evidence for Interventions to Prevent Nephrotoxicity Webcisplatin increases levels of paclitaxel by decreasing renal clearance. Minor/Significance Unknown. conivaptan. conivaptan will increase the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. cortisone.
Cisplatin renal clearance
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WebCisplatin renal clearance, total clearance, and the percentage of the dose excreted unchanged in urine were significantly lower with the longer infusion. Total clearance was 345 +/- 97.0 mL/min/m2 after the two-hour infusion and 268 +/- 70.7 mL/min/m2 after the 24-hour infusion (P less than .0001). WebSep 1, 2014 · Overexpression of Sirt1, a NAD-dependent protein deacetylase, in the proximal tubule cell maintains peroxisome number and reduces renal reactive oxygen species levels which rescued cell apoptosis induced by cisplatin . Downregulation of Klotho gene, an anti-aging gene expressed in the distal convoluted tubules, was observed in …
WebSep 16, 2024 · The mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and 50 mL/min/m 2 following administration of 100 mg/m 2 as 2-hour or 6- to 7-hour infusions, respectively. The renal clearance of free (ultrafilterable) platinum also exceeds the glomerular filtration rate indicating that cisplatin or other platinum-containing ... WebThe mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and 50 mL/min/m2 following administration of 100 mg/m2 as 2-hour or 6- to 7-hour infusions, …
WebApr 12, 2024 · OCT2 exerts its action through cisplatin transport into renal tubular epithelial cells . Consequently, OCT2 is responsible for the cellular uptake of cisplatin and, thus, for its intracellular accumulation. ... Indeed, from 5% to 15% of the patients with both estimated creatinine clearance (eCrCl), expressed in milliliters/minute, ... WebIn humans the renal clearance of cisplatin exceeds the glomerular filtration rate, indicating that cisplatin is secreted across renal tubular cells (Nakamura et al., 2010). Additional …
WebThe renal clearance of free (ultrafilterable) platinum also exceeds the glomerular filtration rate indicating that cisplatin or other platinum-containing molecules are …
WebNational Center for Biotechnology Information flipbook pages to printWebJan 7, 2024 · Most patients had oropharyngeal cancer, 35 patients in the mannitol group and 26 patients in the non-mannitol group. All patients were Caucasian. After the third series of cisplatin, the mean value of 51 Cr-EDTA clearance had declined to 92.3 mL/min (23.1) in the non-mannitol group and to 96.4 mL/min (20.8) in the mannitol group. The ... greater vacationWebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this ... in the nephrotoxicity caused by cisplatin. 3,18,20 These previous reports also elucidated the association between the clearance of cationic drugs and the toxicity of ... greater vallejo recreation district jobsWebIn general, any patient with a GFR70 mL/min should be highlighted as ‘at risk’ from cisplatin renal toxicity. Kintzel PE, Dorr RT. Anticancer drug renal toxicity and elimination: dosing … greater vallejo recreation districtWebFeb 16, 2024 · This drug can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and … flip book photo albumWebClearance of cisplatin, etoposide, and ifosfamide depends on kidney function and dosages should be adjusted in patients with renal impairment. However, there is still limited data … greater usaWebApr 9, 2024 · Cisplatin has been the chemotherapy cornerstone for renal transitional cell carcinoma, but it's not for everyone. Learn about better options for patients with impaired … flipbook photo